Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

Location: Edward Cancer Center - Naperville
Edward Cancer Center - Plainfield
Nancy Knowles Cancer Center - Elmhurst

Purpose:

This phase III trial compares the addition of stereotactic radiosurgery before or after surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation only to the small areas of cancer in the brain and avoids the surrounding normal brain tissue. Surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases.

Sponsor: NRG Oncology

https://clinicaltrials.gov/ct2/show/NCT05438212

Eligibility:

Inclusion Criteria includes:

• Confirmation of 1-4 brain metastases, one of which requires resection
• The maximum diameter of the lesion to be resected must measure > 2.0 cm and < 5.0 cm
• The maximum diameter of the lesions not to be resected must measure < 4.0 cm
• Known active or history of invasive non-central nervous system (CNS) primary cancer within the past 3 years
• Patient is able to medically tolerate surgery and SRS

Exclusion Criteria includes:

• Prior cranial radiotherapy, including whole brain radiotherapy, or SRS to the resection site
• Evidence of leptomeningeal disease (LMD)
• Primary histology of germ cell tumor, small cell carcinoma or lymphoma
• More than one brain metastasis planned for resection
• Inability to undergo MRI with contrast

Time Commitment: Approx. 4 years